تفاعل #52158

معادلة التفاعل

N-BOC-1,3-dihydro-2H-isoindol-1-carboxylic acid

trimethylsilyldiazomethane

→

N-BOC-1,3-dihydro-2H-isoindol-1-carboxylic acid, methyl ester

المذيبات

CH2Cl2

MeOH

ظروف التفاعل

المعالجة

1. 1
   تركيزthe reaction mixture was concentrated in vacuo
2. 2
   أخرىThe residue was azeotroped with toluene

الإجراء التجريبي

To a solution of N-BOC-1,3-dihydro-2H-isoindol-1-carboxylic acid (SNPE, 10 g, 38 mmol) in CH2Cl2 (100 mL) and MeOH (100 mL) at 0° C. was added trimethylsilyldiazomethane dropwise until the yellow color persisted. After stirring at rt for 15 min, the reaction mixture was concentrated in vacuo. The residue was azeotroped with toluene to afford N-BOC-1,3-dihydro-2H-isoindol-1-carboxylic acid, methyl ester which was used without further purification.

المصدر