تفاعل #521560

معادلة التفاعل

1-chloro-3,3-dimethyl-butan-2-one

1,2,4-triazole

potassium carbonate

→

3,3-dimethyl-1-(1,2,4-triazol-1-yl)-butan-2-one

المردود 74.0%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto cool
2. 2
   ترشيحthe inorganic salt was filtered off
3. 3
   تركيزthe filtrate was concentrated in vacuo
4. 4
   أخرىAfter treatment with diisopropyl ether, the oily residue crystallized out
5. 5
   أخرىAfter drying

الإجراء التجريبي

13.45 g (1 mol) of 1-chloro-3,3-dimethyl-butan-2-one, 69 g (1 mol) of 1,2,4-triazole and 140 g (1 mol) of powdered potassium carbonate were heated under reflux in 500 ml of acetone for 6 hours, while stirring. Thereafter, the mixture was allowed to cool, the inorganic salt was filtered off and the filtrate was concentrated in vacuo. After treatment with diisopropyl ether, the oily residue crystallized out. After drying, 123.6 g (74% of theory) of 3,3-dimethyl-1-(1,2,4-triazol-1-yl)-butan-2-one of melting point 63°-65° C. were obtained.

المصدر