تفاعل #52132

معادلة التفاعل

dibenzyl-amine

epichlorohydrin

sodium hydroxide

→

1,2-Epoxy-3-dibenzylaminopropane

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرى3 hours
2. 2
   أخرىat room temperature
3. 3
   استخلاصextracted 3 times with 500 ml of methylene chloride
4. 4
   تجفيفdried over magnesium sulfate
5. 5
   أخرىevaporated under vacuum
6. 6
   أخرىThe remaining oil is flash-chromatographed on silica gel (mobile phase: methylene chloride/hexane/acetone: 20/10/3)

الإجراء التجريبي

At 0° C., 100 g (506.9 millimoles) of dibenzyl-amine (dissolved in 300 ml of methylene chloride) is added dropwise to a thoroughly stirred suspension of 234.51 g (2.53 mol) of epichlorohydrin and 200 ml of 32% sodium hydroxide solution. The mixture is stirred for 2 hours at 0° C. and then 3 hours at room temperature. The mixture is diluted with 3 l of water and extracted 3 times with 500 ml of methylene chloride. The organic phases are combined, dried over magnesium sulfate, and evaporated under vacuum. The remaining oil is flash-chromatographed on silica gel (mobile phase: methylene chloride/hexane/acetone: 20/10/3).

المصدر