تفاعل #51970

معادلة التفاعل

4-acetamidoacetophenone

bromine

→

title compound

المردود 62.5%

N-[4-(2-bromoacetyl)phenyl]acetamide

المردود 62.5%

المذيبات

1,4-dioxane diethyl ether

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe solid was collected by filtration
2. 2
   غسيلwashed with diethyl ether
3. 3
   أخرىdried under high vacuum

الإجراء التجريبي

To a suspension of 4-acetamidoacetophenone (Lancaster, 5.32 g, 0.03 mol) in 1,4-dioxane/diethyl ether (100 mL, 1:2, v/v) was added bromine (1.53 mL, 0.03 mol) via a syringe. The reaction mixture was stirred at room temperature for 4 hours until the color of the mixture was changed from brown to white. The solid was collected by filtration, washed with diethyl ether, and dried under high vacuum to give the title compound as a white solid (4.8 g).

المصدر