تفاعل #5191

معادلة التفاعل

hydrochloric acid

sodium hydroxide

(2S, 4S)-4-(4-methoxybenzylthio)-2-methoxycarbonyl-1-methylpyrrolidine

→

(2S, 4S)-2-carboxy-4-(4-methoxybenzylthio)-1-methylpyrrolidine

المردود 120.2%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىthe reaction mixture was freed from the solvent by evaporation under reduced pressure
2. 2
   أخرىthe residue was dried
3. 3
   تركيزconcentrated by evaporation under reduced pressure

الإجراء التجريبي

5.32 ml of a 1N aqueous solution of sodium hydroxide were added to a solution of 1.31 g of (2S, 4S)-4-(4-methoxybenzylthio)-2-methoxycarbonyl-1-methylpyrrolidine dissolved in 11 ml of methanol, and the mixture was stirred at room temperature for 2 hours. At the end of this time, it was neutralized with 5.32 ml of 1N aqueous hydrochloric acid, and the reaction mixture was freed from the solvent by evaporation under reduced pressure, and the residue was dried and concentrated by evaporation under reduced pressure, to afford 1.5 g of crude (2S, 4S)-2-carboxy-4-(4-methoxybenzylthio)-1-methylpyrrolidine.

المصدر