تفاعل #51908

معادلة التفاعل

ethyl 7-hydroxy-2-(hydroxymethyl)-3-methylthieno[3,2-b]pyridine-6-carboxylate

4-fluorobenzylamine

→

title compound

المردود 85.5%

N-(4-fluorobenzyl)-7-hydroxy-2-(hydroxymethyl)-3-methylthieno[3,2-b]pyridine-6-carboxamide

المردود 85.5%

المذيبات

HCl

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was then cooled to room temperature
2. 2
   درجة الحرارةcooled in the refrigerator for three hours
3. 3
   ترشيحThe resulting mixture was then filtered
4. 4
   غسيلthe obtained solid was washed with 1N HCl several times (50 mL total volume)
5. 5
   أخرىdried in a vacuum oven at 60° C. over night

الإجراء التجريبي

A suspension of 140 mg (0.52 mmol) ethyl 7-hydroxy-2-(hydroxymethyl)-3-methylthieno[3,2-b]pyridine-6-carboxylate in 1.28 mL (11.2 mmol) 4-fluorobenzylamine was heated to 80° C. for 24 hours. The mixture was then cooled to room temperature and added to 10 mL of 1N HCl and then cooled in the refrigerator for three hours. The resulting mixture was then filtered and the obtained solid was washed with 1N HCl several times (50 mL total volume) and dried in a vacuum oven at 60° C. over night to provide 154 mg of the title compound as a tan solid.

المصدر