تفاعل #51881

معادلة التفاعل

4-(2,4-bis{[tert-butyl(dimethyl)silyl]oxy}phenyl)cyclohexanone

benzylamine

→

title compound

المردود 101.5%

N-Benzyl-N-[4-(2,4-bis{[tert-butyl(dimethyl)silyl]oxy}phenyl) cyclohexylidene]amine

المردود 101.5%

المذيبات

Dichloromethane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىTo a flask equipped with magnetic stirrer
2. 2
   ترشيحthe reaction mixture filtered through celite
3. 3
   غسيلwashing with dichloromethane (50 ml)
4. 4
   تركيزThe filtrate was concentrated in vacuo

الإجراء التجريبي

To a flask equipped with magnetic stirrer was added 4-(2,4-bis{[tert-butyl(dimethyl)silyl]oxy}phenyl)cyclohexanone (817 mg, 1.88 mmol). Dichloromethane (50 ml) was added followed by benzylamine (0.82 ml, 7.52 mmol) and activated 4 Å molecular sieves (10.0 g). The reaction mixture was stirred vigorously for 15 hr, then dichloromethane (50 ml) was added and the reaction mixture filtered through celite, washing with dichloromethane (50 ml). The filtrate was concentrated in vacuo affording the title compound (1.00 g, 86%) as a yellow oil. δH(CDCl3) 0.19 (6H, s), 0.26 (6H, s), 0.98 (9H, s), 1.03 (9H, s), 1.51 (1H, m), 1.72 (1H, m), 2.03 (2H, m), 2.45 (1H, m), 2.60 (1H, m), 3.04 (1H, m), 3.22 (1H, m), 4.55 (1H, d), 4.60 (1H, d), 6.31 (1H, d), 6.41 (1H, dd), 6.93 (1H, d), 7.33 (5H, m).

المصدر