تفاعل #51850

معادلة التفاعل

1,2-diphenyl-4-(4-methylphenyl)-3,5-pyrazolidinedione

H2O2

Sodium metabisulfite

→

1,2-Diphenyl-4-hydroxy-4-(4-methylphenyl)-3,5-pyrazolidinedione

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   أخرىexcess acetic acid evaporated off
2. 2
   workup.DISSOLUTIONThe residue was dissolved in hot ethyl acetate (25 ml)
3. 3
   ترشيحbenzene (25 ml) and filtered
4. 4
   درجة الحرارةAfter cooling to room temperature
5. 5
   ترشيحthe mixture was filtered
6. 6
   أخرىthe residue recrystallized from 50% aqueous ethanol (20 ml)
7. 7
   أخرىto give 0.58 g (53%)

الإجراء التجريبي

A mixture of 1,2-diphenyl-4-(4-methylphenyl)-3,5-pyrazolidinedione (1.10 g; 3.2 =mol), 35% H2O2 (0.47 ml; 5.5 mmol), and acetic acid (40 ml) was stirred 16 days at room temperature. Sodium metabisulfite (1.0 g) was added and excess acetic acid evaporated off. The residue was dissolved in hot ethyl acetate (25 ml) and benzene (25 ml) and filtered. After cooling to room temperature, the mixture was filtered and the residue recrystallized from 50% aqueous ethanol (20 ml) to give 0.58 g (53%).

المصدر