تفاعل #518442

معادلة التفاعل

2,4-dichloro-6-methylpyrimidine

pyrrolidine

→

2-chloro-4-methyl-6-pyrrolidin-1-yl-pyrimidine

المردود 73.0%

المذيبات

isopropanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwere treated under ice-
2. 2
   تركيزconcentrated in vacuo
3. 3
   أخرىThe residue was purified on a silica gel chromatography column with CH2Cl2/AcOEt (4/1) as eluent

الإجراء التجريبي

0.815 g (5 mmol) of 2,4-dichloro-6-methylpyrimidine dissolved in in 5 ml isopropanol were treated under ice-cooling dropwise with 0.71 g (10 mmol) pyrrolidine. The mixture was stirred for 1 h at RT the concentrated in vacuo. The residue was purified on a silica gel chromatography column with CH2Cl2/AcOEt (4/1) as eluent to give 0.72 g (73%) of the desired 2-chloro-4-methyl-6-pyrrolidin-1-yl-pyrimidine as an off-white solid. EI mass spectrum, m/e: 197 (M calculated for C9H12N3Cl: 197).

المصدر