تفاعل #5182

معادلة التفاعل

methyl fluorosulfonate

(2S, 4S)-2-(N,N-dimethylcarbamoyl)-4-(4-methoxybenzylthio)-1-methylpyrrolidine

→

title compound

(2S, 4S)-2-(N,N-Dimethylcarbamoyl)-4-(4-methoxybenzylthio)-1,1-dimethylpyrrolidinium fluorosulfonate

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONAt the end of this time, the solvent was distilled off under reduced pressure
2. 2
   غسيلThe residue was repeatedly washed by decantation with hexane
3. 3
   أخرىdried under reduced pressure

الإجراء التجريبي

139 μl of methyl fluorosulfonate were added, whilst ice-cooling, to a solution of 190 mg of (2S, 4S)-2-(N,N-dimethylcarbamoyl)-4-(4-methoxybenzylthio)-1-methylpyrrolidine [prepared as described in step (5) or (11) above] dissolved in 3.8 ml of methylene chloride, and the mixture was stirred at room temperature for 2 hours. At the end of this time, the solvent was distilled off under reduced pressure. The residue was repeatedly washed by decantation with hexane and dried under reduced pressure, to give 356 mg of the title compound as an oil.

المصدر