تفاعل #5181

معادلة التفاعل

hydrochloric acid

sodium hydroxide

(2S, 4S)-4-(4-methoxybenzylthio)-2-methoxycarbonyl-1-methylpyrrolidine

→

(2S, 4S)-2-carboxy-4-(4-methoxybenzylthio)-1-methylpyrrolidine

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was then removed by distillation under reduced pressure
2. 2
   أخرىthe residue was dried

الإجراء التجريبي

1.92 ml of a 1N aqueous solution of sodium hydroxide was added to a solution of 378 mg of (2S, 4S)-4-(4-methoxybenzylthio)-2-methoxycarbonyl-1-methylpyrrolidine [prepared as described in step (10) above] dissolved in 3.84 ml of methanol, and the mixture was stirred at room temperature for 3 hours, At the end of this time, the mixture was neutralized by the addition of 1.92 ml of 1N aqueous hydrochloric acid. The solvent was then removed by distillation under reduced pressure, and the residue was dried, to give crude (2S, 4S)-2-carboxy-4-(4-methoxybenzylthio)-1-methylpyrrolidine.

المصدر