تفاعل #51763

معادلة التفاعل

5-tert-butyl-2-nitro-phenylamine

ammonium thiocyanate

bromine

→

title compound

5-tert-Butyl-2-nitro-4-thiocyanato-phenylamine

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   أخرىThe crude reaction mixture
2. 2
   أخرىwas purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents)

الإجراء التجريبي

The title compound was prepared according to the General Method 13 using 5-tert-butyl-2-nitro-phenylamine (prepared in Example PP-2; 170 g, 876 mmol), ammonium thiocyanate (400 g, 5260 mmol), bromine (140 g, 876 mmol), and MeOH (500 mL). The crude reaction mixture was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents). MS(APCI): 252 (M+H).

المصدر