تفاعل #51762

معادلة التفاعل

bromine

5-isopropyl-2-nitro-phenylamine

sodium thiocyanate

sodium bromide

→

title compound

5-Isopropyl-2-nitro-4-thiocyanato-phenylamine

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   أخرىThe crude reaction mixture
2. 2
   أخرىwas purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents)

الإجراء التجريبي

The title compound was prepared according to General Method 13 using 5-isopropyl-2-nitro-phenylamine (prepared in Example PP-1; 5.4 g, 30 mmol), sodium thiocyanate (14.6 g, 180 mmol), sodium bromide (3.7 g, 35.99 mmol), bromine (5.75 g, 36.0 mmol), and MeOH (100 mL). The crude reaction mixture was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents). MS(APCI): 238 (M+H).

المصدر