تفاعل #516724

معادلة التفاعل

2-indolinone

2-ethyl-4-formylimidazole

2-chlorotrityl resin

piperidine

→

Imidazolyl Indolinone

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated at 80° C. for 20 h
2. 2
   ترشيحThe resin was filtered
3. 3
   غسيلwashed with 30 ml each of acetone, water, dichloromethane, methanol
4. 4
   أخرىdried for 20 min.

الإجراء التجريبي

A mixture of 2-ethyl-4-formylimidazole attached to 2-chlorotrityl resin (4, 78 mg, 0.052 mmol based on 0.67 mmol/g loading), DMF (0.9 ml) and piperidine (0.1 ml) was gently stirred for 45 min. at ambient temperature, afterwhich was added 2-indolinone (5, 70 mg, 0.523 mmol). The resultant mixture was gently stirred and heated at 80° C. for 20 h. The resin was filtered and washed with 30 ml each of acetone, water, dichloromethane, methanol, and another portion of acetone. Finally, the resin was air dried for 20 min.

المصدر