تفاعل #516416

معادلة التفاعل

4′-Hydroxy[1,1′-biphenyl]-4-carboxylic acid

sulfuric acid

methanol

→

title compound

المردود 95.0%

methyl 4′-hydroxy[1,1′-biphenyl]-4-carboxylate

المردود 95.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux temperature for 24 hours
2. 2
   ترشيحfiltered
3. 3
   غسيلThe filter cake was washed with cold methanol (2×25 mL)
4. 4
   أخرىdried under reduced pressure

الإجراء التجريبي

4′-Hydroxy[1,1′-biphenyl]-4-carboxylic acid (5.0 g, 23.34 mmol, purchased from Aldrich Chemical Co.) and sulfuric acid (0.5 mL) in methanol (100 mL) were heated at reflux temperature for 24 hours. The mixture was allowed to cool to ambient temperature and then filtered. The filter cake was washed with cold methanol (2×25 mL) and dried under reduced pressure to provide the title compound (95% yield).

المصدر