تفاعل #515715

معادلة التفاعل

1-benzyl-4-(6-methoxy-2-methylquinolin-8-yl)piperazine

ammonium formate

EtOAc hexane

→

title compound

المردود 95.0%

4-(6-methoxy-2-methylquinolin-8-yl)piperazine

المردود 95.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwere heated
2. 2
   درجة الحرارةat reflux under N2 for 3 hours
3. 3
   ترشيحthe reaction was filtered through celite
4. 4
   غسيلwashing with excess methanol
5. 5
   تركيزThe filtrate was concentrated
6. 6
   workup.ADDITIONdiluted with CH2Cl2 (50 mL)
7. 7
   غسيلwashed with saturated aqueous NaHCO3
8. 8
   استخلاصThe aqueous layer was extracted with CH2Cl2 (2×50 mL)
9. 9
   تجفيفThe combined organic layers were dried over anhydrous sodium sulfate
10. 10
    ترشيحfiltered
11. 11
    تركيزconcentrated in vacuo

الإجراء التجريبي

A mixture of 1-benzyl-4-(6-methoxy-2-methylquinolin-8-yl)piperazine (0.527 g, 1.52 mmol), 10% Pd/C (0.20 g), and ammonium formate (0.96 g, 15.2 mmol) in methanol (10 mL) were heated at reflux under N2 for 3 hours. TLC analysis (35% EtOAc/hexane) indicated only a trace of starting material remained. After cooling to room temperature, the reaction was filtered through celite, washing with excess methanol. The filtrate was concentrated, diluted with CH2Cl2 (50 mL), and washed with saturated aqueous NaHCO3. The aqueous layer was extracted with CH2Cl2 (2×50 mL). The combined organic layers were dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to afford 0.37 g (95%) of the title compound as a yellow oil, which was used in the subsequent reaction without purification.

المصدر