تفاعل #514669

معادلة التفاعل

8-Amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide

2,6-dimethylbenzylchloride

sodium carbonate

potassium iodide

→

title compound

المردود 83.4%

2,3-dimethyl-8-(2,6-dimethylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxamide

المردود 83.4%

المذيبات

acetone

Methylene chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed for 19 h
2. 2
   ترشيحinorganic salts were filtered off
3. 3
   غسيلThe solution was washed with a bicarbonate solution
4. 4
   أخرىthe organic layer was separated
5. 5
   أخرىdried
6. 6
   أخرىthe solvents were evaporated under reduced pressure
7. 7
   أخرىThe residue was purified by column chromatography on silica gel
8. 8
   غسيلthe product was washed with diethyl ether

الإجراء التجريبي

8-Amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide (0.6 g, 2.9 mmol), 2,6-dimethylbenzylchloride (0.45 g, 2.9 mmol), sodium carbonate (1.0 g, 9.4 mmol) and potassium iodide (0.2 g, 1.3 mmol) were added to acetone (25 ml) and refluxed for 19 h. Methylene chloride was added and inorganic salts were filtered off. The solution was washed with a bicarbonate solution, the organic layer was separated, dried and the solvents were evaporated under reduced pressure. The residue was purified by column chromatography on silica gel using methylene chloride:methanol (100:5) as eluent and the product was washed with diethyl ether to give 0.78 g (82%) of the title compound.

المصدر