تفاعل #51461

معادلة التفاعل

ammonium chloride

imidazole

trichloropyrimidine

triethylamine

→

2-imidazolyl-4,6-dichloropyrimidine

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter reaction
2. 2
   استخلاصextracted three times with ethyl acetate
3. 3
   غسيلThe combined organic layers are washed with brine
4. 4
   أخرىdried
5. 5
   ترشيحThe reaction mixture is filtered
6. 6
   أخرىall volatiles removed under reduced pressure

الإجراء التجريبي

One equivalent of imidazole is added in one portion to a solution of one equivalent of trichloropyrimidine and 1.5 equivs of triethylamine in THF. After reaction is complete, the reaction mixture is poured into saturated, aqueous ammonium chloride and extracted three times with ethyl acetate. The combined organic layers are washed with brine and dried. The reaction mixture is filtered and all volatiles removed under reduced pressure. The product, 2-imidazolyl-4,6-dichloropyrimidine (the compound of formula (VIIIa)) is isolated by flash chromatography (20% ethyl acetate in hexane) as an off-white solid.

المصدر