تفاعل #51458

معادلة التفاعل

5-chlorocarbonylphthalid

morpholine

triethylamine

→

5-(4-morpholylcarbonyl)phthalid

المذيبات

THF

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىTHF is evaporated off in vacuo
2. 2
   درجة الحرارةThe solution is cooled to 5° C.
3. 3
   غسيلwashed with water (100 ml)

الإجراء التجريبي

A solution of 5-chlorocarbonylphthalid (39 g, 0.2 mole) in THF (400 ml) is added to a solution of morpholine (22 g. 0.25 mole) and triethylamine (26 g, 0.25 mole) in THF (200 ml) at 0° C. The mixture is stirred for 1 hour and is allowed to warm to room temperature. The reaction mixture is then poured into ice water ( 500 ml). THF is evaporated off in vacuo and the pH of the solution is adjusted to pH=2. The solution is cooled to 5° C. and the precipitated crystals are filtred off and washed with water (100 ml).

المصدر