تفاعل #5144

معادلة التفاعل

2-(2-(2-chloroethoxy)ethoxy)-ethanol

m-nitrophenol

N,N-dimethylformamide

potassium carbonate

→

2-(2-(2-(3-nitrophenoxy)ethoxy)ethoxy)ethanol

المذيبات

water

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGAfter stirring the mixture for one hour at 80° C.
2. 2
   استخلاصthe ethyl acetate layer was extracted
3. 3
   غسيلThe ethyl acetate layer was washed with 200 ml of water
4. 4
   تركيزconcentrated
5. 5
   أخرىto remove ethyl acetate

الإجراء التجريبي

While stirring a mixture of 27.8 g of m-nitrophenol, 120 ml of N,N-dimethylformamide, and 25 g of potassium carbonate at 80° C., 37 g of 2-(2-(2-chloroethoxy)ethoxy)-ethanol was added dropwise to the mixture. After stirring the mixture for one hour at 80° C., 200 ml of ethyl acetate and 200 ml of water were added to the reaction mixture and the ethyl acetate layer was extracted. The ethyl acetate layer was washed with 200 ml of water and concentrated to remove ethyl acetate to provide 2-(2-(2-(3-nitrophenoxy)ethoxy)ethoxy)ethanol (1-A).

المصدر