تفاعل #514362

معادلة التفاعل

1-Butoxycarbonylamino-4-(1-iminoethylamino)but-2-yne

HCl dioxane

→

1-amino-4-(1-iminoethylamino)but-2-yne

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter this time the mother liquor was decanted off
2. 2
   أخرىto remove residual solvent
3. 3
   أخرىThe resulting material was triturated with dry diethyl ether (×2)
4. 4
   ترشيحfiltered off
5. 5
   غسيلwashed with more dry diethyl ether
6. 6
   أخرىThe yellow solid was finally dried in a drying pistol

الإجراء التجريبي

1-Butoxycarbonylamino-4-(1-iminoethylamino)but-2-yne (0.332 g) was deprotected by treatment with 4 N HCl/dioxane (3 ml) at 0° C. and stirring at 0° C. for 1h then at room temperature for 1h. After this time the mother liquor was decanted off and the sticky residue subjected to an oil pump vacuum to remove residual solvent. The resulting material was triturated with dry diethyl ether (×2), filtered off and washed with more dry diethyl ether. The yellow solid was finally dried in a drying pistol to yield 1-amino-4-(1-iminoethylamino)but-2-yne 2.5hydrochloride (0.184 g), Mpt 182°-185° C.(dec), FAB M.S. M+1+126.

المصدر