تفاعل #513402

معادلة التفاعل

2,4-dichloro-6-methylpyrimidine

N-chloro succinimide

benzoyl peroxide

→

2,4-dichloro-6-chloromethyl-pyrimidine

المردود 40.0%

المذيبات

carbon tetrachloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed for 24 hr
2. 2
   ترشيحthe mixture was filtered
3. 3
   أخرىevaporated in vacuo
4. 4
   أخرىThe residue was purified by silica gel column chromatography (eluent, from hexane to 2% ether in hexane)

الإجراء التجريبي

A mixture of 2,4-dichloro-6-methylpyrimidine (12.5 g, 76.65 mmol), N-chloro succinimide (12.28 g, 92 mmol), and benzoyl peroxide (2.78 g, 11.5 mmol) in carbon tetrachloride (150 ml) was refluxed for 24 hr. After cooling to room temperature, the mixture was filtered and evaporated in vacuo. The residue was purified by silica gel column chromatography (eluent, from hexane to 2% ether in hexane) to afford 6 g (40%) of 2,4-dichloro-6-chloromethyl-pyrimidine as a white solid. 1H NMR (200 MHz, CDCl3) δ 4.58 (2H, s), 7.55 (1H, s).

المصدر