تفاعل #51338
ord-67ada832f8c24662847c20f8da7631de
معادلة التفاعل
L-alanine
thionyl chloride
isobutanol
→
L-alanine iso-butyl ester hydrochloride
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1أخرىthe volatiles were removed completely on a rotavapor of 90° C. under reduced pressure
الإجراء التجريبي
A mixture of 35.64 g (0.4 mol) of (D,L)-alanine (Aldrich) (or L-alanine (Aldrich)); 44 mL (0.6 mol) of thionyl chloride (Aldrich) and 200 mL of isobutanol was refluxed for 1.5 hours and the volatiles were removed completely on a rotavapor of 90° C. under reduced pressure to give (D,L)-alanine iso-butyl ester hydrochloride (or L-alanine iso-butyl ester hydrochloride), which was pure enough to be used for further transformations.