تفاعل #51326

ord-8971890c899441279261f72e668f6918

معادلة التفاعل

[N-]=[N+]=Nc1ccc(N)cc1
4-azidoaniline
CC(=O)C(=O)OCC(C)C
iso-butyl pyruvate
→
CC(C)COC(=O)[C@H](C)Nc1ccc(N=[N+]=[N-])cc1
title compound
CC(C)COC(=O)[C@H](C)Nc1ccc(N=[N+]=[N-])cc1
N-(4-azidophenyl)alanine iso-butyl ester

المتفاعلات

[N-]=[N+]=Nc1ccc(N)cc1
4-azidoaniline
CC(=O)C(=O)OCC(C)C
iso-butyl pyruvate

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىThe reaction was monitored by tlc on silica gel (Rf=0.3 in 25% EtOAc/hexanes) and purification

الإجراء التجريبي

Following General Procedure AA above and using 4-azidoaniline (Aldrich) and iso-butyl pyruvate (prepared by following General Procedure AO above), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel (Rf=0.3 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06849650B2uspto-grants-2005_02