تفاعل #51315

معادلة التفاعل

3,4-dichloroaniline

iso-butyl 4-methyl-2-oxopentanoate

→

title compound

N-(3,4-dichlorophenyl)leucine iso-butyl ester

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction was monitored by tlc on silica gel (Rf=0.6 in 25% EtOAc/hexanes) and purification

الإجراء التجريبي

Following General Procedure AA above and using 3,4-dichloroaniline (Aldrich) and iso-butyl 4-methyl-2-oxopentanoate (prepared by following General Procedure AO above using 4-methyl-2-oxovaleric acid (Fluka) and iso-butanol), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel (Rf=0.6 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

المصدر