تفاعل #51243

معادلة التفاعل

(5R)-5-(hydroxymethyl)pyrrolidin-2-one

ethyl vinyl ether

trifluoroacetic acid

→

(5R)-5-(1-ethoxyethoxymethyl)pyrrolidin-2-one

المردود 102.0%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   أخرىthe reaction was partitioned between methylene chloride (150 mL) and aqueous sodium bicarbonate solution (150 mL)
2. 2
   أخرىthe phases were separated
3. 3
   تجفيفThe organic phase was dried (K2CO3)
4. 4
   ترشيحfiltered
5. 5
   أخرىThe filtrate was evaporated under reduced pressure

الإجراء التجريبي

To a solution of (5R)-5-(hydroxymethyl)pyrrolidin-2-one (Aldrich, 8.86 g, 77 mmol) in 70 mL of chloroform at room temperature under an argon atmosphere was added ethyl vinyl ether (10.4 mL, 108 mmol) and catalytic anhydrous trifluoroacetic acid (0.2 mL). After stirring for 3 hours, the reaction was partitioned between methylene chloride (150 mL) and aqueous sodium bicarbonate solution (150 mL) and the phases were separated. The organic phase was dried (K2CO3) and filtered. The filtrate was evaporated under reduced pressure to give 14.7 g of the (5R)-5-(1-ethoxyethoxymethyl)pyrrolidin-2-one.

المصدر