تفاعل #51234

معادلة التفاعل

N-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

morpholine

1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide

1-hydroxybenzotriazole

hydrochloric acid

→

4-(morpholinocarbonyl)piperidine.hydrochloride

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىreaction

الإجراء التجريبي

A mixture comprising N-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (700 mg), morpholine (319 μL), 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (702 mg), 1-hydroxybenzotriazole (495 mg) and N,N-dimethylformamide (9 ml) was stirred at room temperature for 16 hours to undergo reaction, and the resulting compound was acid-treated with hydrochloric acid to obtain 4-(morpholinocarbonyl)piperidine.hydrochloride.

المصدر