تفاعل #51219

معادلة التفاعل

2-chloro-5-nitropyridine

tetrahydrofuran

trans-4-aminocyclohexanol

triethylamine

tetrahydrofuran

→

trans-4-(5-nitro-2-pyridylamino)cyclohexanol

المذيبات

Water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas further added
2. 2
   درجة الحرارةunder ice-cooling
3. 3
   استخلاصthe mixture was extracted with chloroform
4. 4
   غسيلThe extract was washed with brine
5. 5
   تجفيفdried over anhydrous sodium sulfate
6. 6
   أخرىthe solvent was removed under reduced pressure
7. 7
   أخرىThe residue was purified by silica gel flash column chromatography (solvent: ethyl acetate-hexane (2:1))

الإجراء التجريبي

To 150 ml of a tetrahydrofuran suspension containing 10 g of trans-4-aminocyclohexanol was added 15ml of triethylamine, 50 ml of a tetrahydrofuran solution containing 2-chloro-5-nitropyridine was further added thereto under ice-cooling, and then, the mixture was stirred at room temperature for 18 hours. Water was added to the reaction mixture and the mixture was extracted with chloroform. The extract was washed with brine, dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. The residue was purified by silica gel flash column chromatography (solvent: ethyl acetate-hexane (2:1)) to obtain 8.52 g of trans-4-(5-nitro-2-pyridylamino)cyclohexanol.

المصدر