تفاعل #511792

معادلة التفاعل

5-(3-(cyclopentyloxy)-4-methoxyphenyl)pyridazin-3-one

sodium hydride

3-pentylbromide

→

title compound

5-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-(3-pentyl)pyridazin-3-one

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   workup.ADDITIONwas added dropwise
3. 3
   workup.STIRRINGstirred for 18 hours
4. 4
   workup.ADDITIONThe reaction mixture was poured into ice-cold water
5. 5
   استخلاصextracted with ethyl acetate
6. 6
   غسيلThe organic layer was washed with brine
7. 7
   تجفيفdried over anhydrous sodium sulfate
8. 8
   ترشيحThe residue that had been filtered
9. 9
   تركيزconcentrated
10. 10
    أخرىwas purified by flash chromatography

الإجراء التجريبي

To 5-(3-(cyclopentyloxy)-4-methoxyphenyl)pyridazin-3-one prepared in Working Example 5, sodium hydride was added and stirred for 1 hour. Then, 3-pentylbromide dissolved in dimethylformamide was added dropwise and stirred for 18 hours. The reaction mixture was poured into ice-cold water and extracted with ethyl acetate. The organic layer was washed with brine, and then dried over anhydrous sodium sulfate. The residue that had been filtered and concentrated was purified by flash chromatography to obtain the title compound.

المصدر