تفاعل #51163

معادلة التفاعل

2-chloro-6-methoxy-3-nitropyridine

sodium thiomethoxide

→

6-methoxy-2-methylthio-3-nitropyridine

المردود 60.5%

المذيبات

methanol

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwhile being cooled with ice
2. 2
   ترشيحthe precipitated crystal was filtered

الإجراء التجريبي

A methanol (100 ml) solution of 2-chloro-6-methoxy-3-nitropyridine (2.0 g, 10.4 mmol) was added dropwise to a methanol (20 ml) solution of sodium thiomethoxide (805 mg, 10.9 mmol) while being cooled with ice, and the temperature thereof was raised to the room temperature and the mixed solution was stirred for 17 hours and the precipitated crystal was filtered to obtain 1.26 g (yield 59%) of 6-methoxy-2-methylthio-3-nitropyridine as a yellow powdery crystal.

المصدر