تفاعل #51010

معادلة التفاعل

3-methoxy-6-(5-chloro-3-methyl-benzofuran-2-sulfonyl)-pyridazine

HCl

→

desired product

6-(5-Chloro-3-methyl-benzofuran-2-sulfonyl)-2H-pyridazin 2H-pyridazin-3-one

المذيبات

dioxane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture was cooled
2. 2
   أخرىevaporated to dryness
3. 3
   workup.ADDITIONWater (20 mL) was added to the residue
4. 4
   أخرىThe resulting precipitate was collected
5. 5
   أخرىcrystallized from ethanol

الإجراء التجريبي

A mixture of 3-methoxy-6-(5-chloro-3-methyl-benzofuran-2-sulfonyl)-pyridazine (22.2 mmol, 7.5 g), conc. HCl (5 mL), and dioxane (50 mL) was heated at 100° C. for 2 hours. The reaction mixture was cooled and evaporated to dryness. Water (20 mL) was added to the residue. The resulting precipitate was collected and crystallized from ethanol to obtain the desired product: 6-(5-chloro-3-methyl-benzofuran-2-sulfonyl)-2H-pyridazin-2H-pyridazin-3-one (89%, 6.42 g).

المصدر