تفاعل #51004

معادلة التفاعل

( g )

2-(2,4-dichlorophenyl)benzoxazol-5-ol

(S)-(+)-epichlorohydrin

potassium carbonate

2-(2,4-dichlorophenyl)benzoxazol-5-ol

→

2-(2,4-dichlorophenyl)-5-(oxiran-2-ylmethoxy)benzoxazole

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto reflux
2. 2
   درجة الحرارةto cool
3. 3
   ترشيحfiltered through Celite 512
4. 4
   أخرىThe filtrate was evaporated under reduced pressure
5. 5
   أخرىto yield an oil
6. 6
   أخرىThe oil was chromatographed on silica gel
7. 7
   غسيلeluting with 20% ethyl acetate/hexanes

الإجراء التجريبي

A mixture of 2-(2,4-dichlorophenyl)benzoxazol-5-ol, a compound of formula (g) (6.0 g, 36 mmol), (S)-(+)-epichlorohydrin (3.3 g, 315 mmol), a compound of formula (b) (20 ml, 182 mmol), and potassium carbonate (20 g, 144 mmol) in acetone (100 ml) was heated to reflux and stirred overnight. The solution was allowed to cool and filtered through Celite 512. The filtrate was evaporated under reduced pressure, to yield an oil. The oil was chromatographed on silica gel, eluting with 20% ethyl acetate/hexanes, to provide 2-(2,4-dichlorophenyl)-5-(oxiran-2-ylmethoxy)benzoxazole as a white solid (6.2 g, 28 mmol).

المصدر