تفاعل #50998

معادلة التفاعل

triethylamine

1-(tert-butoxycarbonyl)-2-tert-butyl-3-methyl-4-imidazolidinone

(2S)-2-methylpiperazine

→

tert-butyl (3S)-3-methylpiperazinecarboxylate

المذيبات

chloroform

chloroform

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water
2. 2
   أخرىthe solvent removed in vacuo
3. 3
   أخرىThe residue was purified by column chromatography

الإجراء التجريبي

1-(tert-butoxycarbonyl)-2-tert-butyl-3-methyl-4-imidazolidinone (2 g, 8.3 mmol) (BOC—ON), in chloroform (15 ml), was added to (2S)-2-methylpiperazine (5 g, 50 mmol), a compound of formula (A), in a mixture of triethylamine (1.25 g, 12.5 mmol) and chloroform. The mixture was stirred for about 15 hours and then washed with water, the solvent removed in vacuo. The residue was purified by column chromatography, to give tert-butyl (3S)-3-methylpiperazinecarboxylate, a compound of formula (B).

المصدر