تفاعل #508780

ord-bb2b0db591fd4716ad6c8d24ffed1ca7

معادلة التفاعل

CON(C)C(=O)[C@H](C)NC(=O)OC(C)(C)C
(2S)-2-[(tert-butoxy)carbonylamino]-N-methoxy-N-methylpropanamide
C[C@@H](NC(=O)OC(C)(C)C)C(=O)O
boc-D-alanine
→
CON(C)C(=O)[C@@H](C)NC(=O)OC(C)(C)C
title compound
المردود 88.0%
CON(C)C(=O)[C@@H](C)NC(=O)OC(C)(C)C
(2R)-2-[(tert-Butoxy)carbonylamino]-N-methoxy-N-methylpropanamide
المردود 88.0%

المتفاعلات

CON(C)C(=O)[C@H](C)NC(=O)OC(C)(C)C
(2S)-2-[(tert-butoxy)carbonylamino]-N-methoxy-N-methylpropanamide
C[C@@H](NC(=O)OC(C)(C)C)C(=O)O
boc-D-alanine

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound was prepared as (2S)-2-[(tert-butoxy)carbonylamino]-N-methoxy-N-methylpropanamide with boc-D-alanine (20 grams, 105.7 mmol) to give the title compound (21.7 g, 88%): ES-MS (m/z) 233.2 [M+l]+.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08101588B2uspto-grants-2012_01