تفاعل #5086

معادلة التفاعل

4-(3-chlorophenyl)-piperazine

sodium hydride

epichlorohydrin

→

4-(3-chlorophenyl)-1-(2,3-epoxypropyl)piperazine

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe reaction mixture was extracted with 100 ml of ethyl acetate
2. 2
   غسيلthe extract was washed 5 times with 100 ml of water
3. 3
   تجفيفdried with anhydrous magnesium sulfate
4. 4
   أخرىThe solvent was removed by evaporation
5. 5
   أخرىto obtain the residue which
6. 6
   أخرىwas purified by means of a silica gel column chromatography (eluent: ethyl acetate: n-hexane=1:1)

الإجراء التجريبي

To a mixture of 1.50 g of 4-(3-chlorophenyl)-piperazine and 0.31 g of sodium hydride was added 2.4 ml of epichlorohydrin and the reaction mixture as stirred at room temperature for 30 minutes. After the reaction was completed, the reaction mixture was extracted with 100 ml of ethyl acetate, and the extract was washed 5 times with 100 ml of water, then dried with anhydrous magnesium sulfate. The solvent was removed by evaporation to obtain the residue which was purified by means of a silica gel column chromatography (eluent: ethyl acetate: n-hexane=1:1) to obtain 1.66 g of 4-(3-chlorophenyl)-1-(2,3-epoxypropyl)piperazine as in the form of an oily substance.

المصدر