تفاعل #508106

معادلة التفاعل

2-ethoxycarbonylmethyl-5-hydroxy-1-(4-piperidin-4-ylphenyl)indole-3-carboxylic acid ethyl ester

2-Ethoxycarbonylmethyl-5-hydroxy-1-(4-piperidin-4-ylphenyl)indole-3-carboxylic acid ethyl ester

4-trifluoromethylphenylboronic acid

→

sub-title compound

2-Ethoxycarbonylmethyl-1-(4-piperidin-4-ylphenyl)-5-(4-trifluoromethylphenoxy)indole-3-carboxylic acid ethyl ester

ظروف التفاعل

الإجراء التجريبي

The sub-title compound was prepared in accordance with step (c) Example 1 from 2-ethoxycarbonylmethyl-5-hydroxy-1-(4-piperidin-4-ylphenyl)indole-3-carboxylic acid ethyl ester (203 mg, 0.45 mmol, see step (b) Example 17) and 4-trifluoromethylphenylboronic acid. Yield 160 mg (60%).

المصدر