تفاعل #508104

معادلة التفاعل

2-ethoxycarbonylmethyl-5-hydroxy-1-(4-morpholin-4-yl-phenyl)indole-3-carboxylic acid ethyl ester

2-Ethoxycarbonylmethyl-5-hydroxy-1-(4-morpholin-4-yl-phenyl)indole-3-carboxylic acid ethyl ester

4-trifluoromethylphenylboronic acid

→

sub-title compound

2-Ethoxycarbonylmethyl-1-(4-morpholin-4-ylphenyl)-5-(4-trifluoromethylphenoxy)indole-3-carboxylic acid ethyl ester

ظروف التفاعل

الإجراء التجريبي

The sub-title compound was prepared in accordance with step (c) Example 1 from 2-ethoxycarbonylmethyl-5-hydroxy-1-(4-morpholin-4-yl-phenyl)indole-3-carboxylic acid ethyl ester (158 mg, 0.35 mmol, see step (b) Example 15) and 4-trifluoromethylphenylboronic acid (100 mg, 0.53 mmol). Yield 120 mg (57%).

المصدر