تفاعل #50757

معادلة التفاعل

2-(5-amino-1,2,4-thiadiazol-3-yl)-2-fluoromethoxyiminoacetic acid hydrate

phosphorus pentachloride

isopropyl ether

→

title compound

المردود 106.0%

2-(5-amino-1,2,4-thiadiazol-3-yl)-2-fluoromethoxyiminoacetyl chloride . hydrochloride

المردود 106.0%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   أخرىto precipitate crystals
2. 2
   ترشيحThe resulting crystals were collected by filtration
3. 3
   غسيلwashed with 20 ml of isopropyl ether
4. 4
   أخرىdried

الإجراء التجريبي

In 50 ml of methylene chloride, 10.0 g (0.044 mol) of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2-fluoromethoxyiminoacetic acid hydrate were suspended, followed by the addition of 13.3 g (0.064 mol) of phosphorus pentachloride at -20° C. After stirring for 30 minutes, 100 ml of isopropyl ether were added dropwise to the reaction mixture to precipitate crystals. The resulting crystals were collected by filtration, washed with 20 ml of isopropyl ether and then dried, whereby 9.33 g of a title compound were obtained (yield: 77%, purity: 89.7%).

المصدر