تفاعل #50738

معادلة التفاعل

1,4,7,10-tetraazacyclododecane N,N',N",N'"-tetraacetic acid

1,4,8,11-tetraazacyclotetradecane N,N',N",N'"-tetraacetic acid

→

1,4,7,10-tetraazacyclododecane

Formula II

1,4,8,11-tetraazacyclotetradecane

ظروف التفاعل

المعالجة

1. 1
   أخرىAccordingly, the invention provides a method

الإجراء التجريبي

Accordingly, the invention provides a method for the synthesis of 1,4,7,10-tetraazacyclododecane N,N',N",N'"-tetraacetic acid (DOTA) and 1,4,8,11-tetraazacyclotetradecane N,N',N",N'"-tetraacetic acid (TETA) (Formula I). For this purpose 1,4,7,10-tetraazacyclododecane and 1,4,8,11-tetraazacyclotetradecane (Formula II) are provided and cyanomethylated using acid, formaldehyde, and cyanide compound yielding a tetranitrile (Formula III) which precipitates upon the addition of base.. The tetranitrile (Formula III) is hydrolyzed followed by acidification, evaporation to dryness, reconstitution and precipitation to give DOTA or TETA. ##STR5##

المصدر