تفاعل #5070

معادلة التفاعل

Potassium fluoride

Methyl 3-iodobenzoate

vinyl tributyltin

→

Methyl 3-ethylbenzoate

المذيبات

water

toluene

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe solution was heated
2. 2
   درجة الحرارةat reflux
3. 3
   workup.STIRRINGto stir under N2 for 15 minutes
4. 4
   غسيلwashed with water
5. 5
   استخلاصThe organic extract
6. 6
   تجفيفwas dried (MgSO4)
7. 7
   أخرىevaporated in vacuo

الإجراء التجريبي

Methyl 3-iodobenzoate (13 g) and vinyl tributyltin (20 g) were dissolved in toluene (100 ml) and tetrakis(triphenylphosphine)palladium (0) (500 mg) added. The solution was heated at reflux with stirring under N2 for 1 day. Potassium fluoride (3 g) in water (50 ml) was added and the reaction mixture was allowed to stir under N2 for 15 minutes. The product was taken up in ethyl acetate and washed with water and then brine (×2). The organic extract was dried (MgSO4) and evaporated in vacuo.

المصدر