تفاعل #506473

معادلة التفاعل

7-(benzyloxy)-1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-(chloromethyl)-1H-imidazo[4,5-c]quinoline

acetic acid

→

2-[7-(benzyloxy)-2-(chloromethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethanol

المردود 104.2%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىThe heat was removed
2. 2
   تركيزthe greenish homogeneous solution was concentrated to dryness
3. 3
   أخرىisolated by vacuum filtration
4. 4
   غسيلwashed with diethyl ether (100 mL)
5. 5
   أخرىdried on vacuum funnel

الإجراء التجريبي

A 500 mL round bottom flask was charged with 7-(benzyloxy)-1-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-(chloromethyl)-1H-imidazo[4,5-c]quinoline (30 g, 0.06 mol), acetic acid (300 mL), and water (60 mL). The suspension was heated at 50° C. for 24 hours. The heat was removed and the greenish homogeneous solution was concentrated to dryness. The solid was stirred in diethyl ether (300 mL) for 1 hour, isolated by vacuum filtration, washed with diethyl ether (100 mL), and dried on vacuum funnel to provide 23 g of 2-[7-(benzyloxy)-2-(chloromethyl)-1H-imidazo[4,5-c]quinolin-1-yl]ethanol as a green solid.

المصدر