تفاعل #50640

معادلة التفاعل

6-hydroxy-7-phenylmethoxy-2H-1-benzopyran-2-one

isopropylbromide

potassium carbonate

potassium iodide

→

7-hydroxy-6-(1-methylethoxy)-2H-1-benzopyran-2-one

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحAfter filtration the filtrate
2. 2
   أخرىis evaporated
3. 3
   أخرىthe product recrystallized from isopropanol, yield: 57.7 g (100%) 6-(1-methyl-ethoxy)-7-(phenylmethoxy)-2H-1-benzopyran-2-one
4. 4
   أخرىThis is followed by evaporation and purification
5. 5
   أخرى24.65 g (69%), fusion point 121°-122° C. (from isopropanol)

الإجراء التجريبي

50.0 g (186 mmol) 6-hydroxy-7-phenylmethoxy-2H-1-benzopyran-2-one, 36.3 ml (387 mmol) isopropylbromide, 51.5 g (373 mmol) potassium carbonate and 5.0 g potassium iodide are agitated in 500 ml DMF for 14 h at 80° C. After filtration the filtrate is evaporated and the product recrystallized from isopropanol, yield: 57.7 g (100%) 6-(1-methyl-ethoxy)-7-(phenylmethoxy)-2H-1-benzopyran-2-one. Of this 50.0 g (161 mmol) are agitated in 100 ml of glacial acetic acid and 90 ml concentrated hydrochloric acid for 2.5 h at 70° C. This is followed by evaporation and purification using column chromatography on silica gel (eluent: chloroform and methanol 98/2 H 95/5): 24.65 g (69%), fusion point 121°-122° C. (from isopropanol).

المصدر