تفاعل #50635

معادلة التفاعل

scopoletine

epichlorohydrin

potassium carbonate

potassium iodide

→

(±)-6-methoxy-7-(oxiranylmethoxy)-2H-1-benzopyran-2-one

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter vacuum evaporation
2. 2
   استخلاصextraction
3. 3
   أخرىwith hot ethanol re-evaporation
4. 4
   أخرىfusion point 143°-145° C. (from ethanol)

الإجراء التجريبي

25.0 g (130 mmol) of scopoletine, 15.3 ml (196 mmol) epichlorohydrin, 36.0 g (260 mmol) potassium carbonate and 2.5 g of potassium iodide are agitated in 500 ml DMF under nitrogen for 3 h at 80° C. After vacuum evaporation and repeated extraction with hot ethanol re-evaporation was performed. 21.2 g (66%); fusion point 143°-145° C. (from ethanol).

المصدر