تفاعل #5063

معادلة التفاعل

3-bromoquinoline

butyllithium

1-methylpiperid-4-one

→

expected product

المردود 53.8%

3-(4-Hydroxy-1-methylpiperid-4-yl)quinoline

المردود 53.8%

المذيبات

hexane

ظروف التفاعل

الإجراء التجريبي

95.01 g of 3-bromoquinoline were treated with 200 ml of a 2.5M solution of butyllithium in hexane and 51.62 g of 1-methylpiperid-4-one in accordance with the procedure described in Stage A of Example 1, in order to obtain the expected product.

المصدر