تفاعل #50495

معادلة التفاعل

2-imino-3-(4-pyridylmethyl)thiazolidine

nitric acid

→

2-nitroimino-3-(4-pyridylmethyl)thiazolidine

المذيبات

sulfuric acid

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONthe reaction mixture was poured
2. 2
   أخرىonto crushed ice
3. 3
   استخلاصTwice extract with dichloromethan
4. 4
   workup.ADDITIONby treating in the usual way

الإجراء التجريبي

5.8 g of 2-imino-3-(4-pyridylmethyl)thiazolidine was added to 20 ml of conc. sulfuric acid at -5°~0° C. 6 ml of fuming nitric acid was then added dropwise to the solution at the same temperature. After stirring for 30 minutes at 0°~5° C., the reaction mixture was poured onto crushed ice. Twice extract with dichloromethan followed by treating in the usual way yielded 1.4 g of desired 2-nitroimino-3-(4-pyridylmethyl)thiazolidine.

المصدر