تفاعل #50494

معادلة التفاعل

2-nitroiminothiazolidine

potassium carbonate

2-chloro-5-pyridylmethylchloride

→

3-(2-chloro-5-pyridylmethyl)-2-(nitroimino)thiazolidine

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed for 5 hours
2. 2
   أخرىAfter the reaction
3. 3
   أخرىmost of the acetonitrile was removed by distillation and water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   أخرىAs the solid product was separated
6. 6
   ترشيحit was collected by filtration
7. 7
   أخرىThe crude material was recrystallized from ethanol

الإجراء التجريبي

A mixture of 2.9 g of 2-nitroiminothiazolidine, 2.9 g of anhydrous potassium carbonate, 3.2 g of 2-chloro-5-pyridylmethylchloride and 50 ml of acetonitrile was refluxed for 5 hours with vigorously stirring. After the reaction, most of the acetonitrile was removed by distillation and water was added to the residue. As the solid product was separated, it was collected by filtration. The crude material was recrystallized from ethanol to give desired 3-(2-chloro-5-pyridylmethyl)-2-(nitroimino)thiazolidine.

المصدر