تفاعل #50475

معادلة التفاعل

methyl 4-chlorosalicylate

methyl 3-bromopropionate

potassium carbonate

→

desired material

المردود 102.6%

4- Chloro-2-(2-methoxy-1-methyl-2-oxoethoxy)benzoic acid, methyl ester

المردود 102.6%

المذيبات

dimethyl formamide

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe mixture was extracted with ether
2. 2
   غسيلthe organics were washed with water
3. 3
   أخرىThe organic layer was dried
4. 4
   أخرىevaporated

الإجراء التجريبي

A solution of methyl 4-chlorosalicylate (5.0 g) in dimethyl formamide (10 ml) was treated sequentially with methyl 3-bromopropionate (4.0 g) and potassium carbonate (6.0 g). The mixture was stirred at room temperature for 18 hrs and diluted with water. The mixture was extracted with ether and the organics were washed with water. The organic layer was dried and evaporated to give the desired material (6.7 g) as a low melting solid. NMR: 7.8 (d, 1H), 7.2 (m 1H), 6.9 (m, 1H), 4.8 (q, 1H), 3.9 (s, 3H), 3.8 (s, 3H), 1.7 (d, 3H).

المصدر