تفاعل #504714

معادلة التفاعل

6-Bromonaphthalene-2-carbonyl chloride

TMS diazomethane

→

1-(6-bromonaphthalen-2-yl)-2-diazoethanone

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىice bath was removed
2. 2
   أخرىReaction mixture
3. 3
   أخرىevaporated under vacuum

الإجراء التجريبي

6-Bromonaphthalene-2-carbonyl chloride (27.0 g, crude) was dissolved in dichloromethane (330 mL) and cooled to 0° C. TMS diazomethane solution (100 mL, 2 M in DCM) was added, and ice bath was removed. Reaction mixture was stirred for 16 hours and evaporated under vacuum, giving 1-(6-bromonaphthalen-2-yl)-2-diazoethanone (34.7 g, crude) as an orange solid.

المصدر