تفاعل #50389

معادلة التفاعل

2-aminoindan-5-yl-3-pyridyl ketone

p-toluenesulphonic acid chloride

triethylamine

→

2-(4-Toluenesulphonylamino)indan-5-yl-3-pyridyl ketone

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter 4 hours the suspension is rotary-evaporated to dryness
2. 2
   ترشيحsuction filtered

الإجراء التجريبي

21 g of 2-aminoindan-5-yl-3-pyridyl ketone are dissolved together with 18.9 g of p-toluenesulphonic acid chloride in 250 ml of methylene chloride. Then 9.2 g of triethylamine are added dropwise. After 4 hours the suspension is rotary-evaporated to dryness. The residue is suspended in water, made alkaline with sodium hydroxide solution and then suction filtered.

المصدر