تفاعل #50364

معادلة التفاعل

5-hydroxy-3,4-dihydro-1(2H)-naphthalenone

(R)-(-)-epichlorhydrine

→

oxirane (S)-5-(2,3-epoxypropoxy)-3,4-dihydro-1(2H)-naphthalenone

ظروف التفاعل

الإجراء التجريبي

reacting 5-hydroxy-3,4-dihydro-1(2H)-naphthalenone with (R)-(-)-epichlorhydrine, in an aprotic solvent in the presence of a strong base at a temperature of over 90° C., to give the intermediate chiral oxirane (S)-5-(2,3-epoxypropoxy)-3,4-dihydro-1(2H)-naphthalenone with an optical purity greater than 95%, and then,

المصدر